INJECTABLES

XEOMIN®

XEOMIN® is a prescription medication used in facial aesthetics to temporarily improve the appearance of moderate to severe glabellar frown lines between the eyes (glabellar lines) in adults.

XEOMIN® contains botulinum toxin type A, a protein purified from the bacterium Clostridium botulinum.

XEOMIN® is also sometimes referred to as incobotulinumtoxinA.

XEOMIN® in Aesthetics: How Does it Work?
When you squint or frown, the muscles between your brows contract, causing the skin to furrow and fold. These lines that occur due to facial mimics are referred to as dynamic lines. Over time, as your skin ages and loses some of its elasticity, these repeated contractions can cause persistent frown lines.

Botulinum toxin type A – the active ingredient in XEOMIN® – is used in facial aesthetic treatment to treat dynamic lines like glabellar frown lines. It acts on nerve endings in muscles to prevent muscle fibers from contracting. By reducing these contractions, XEOMIN® can temporarily reduce the frown lines on your forehead between your eyes.

IS XEOMIN® PROVEN?
XEOMIN® (incobotulinumtoxinA) for injection, for intramuscular use, was proven effective in two randomized, double-blind, multicenter, placebo-controlled clinical trials of more than 540 adult patients in the treatment of glabellar frown lines. The average age of patients in the study was 46 years. Patients received 20 Units of XEOMIN® and were classified as responders if they had a 2-grade improvement on a 4-point scale as assessed by the physician and patient. Using these criteria, treatment success was higher with XEOMIN® than placebo on day 30 in both studies (60% and 48% vs. 0% for placebo in both studies). Based on these trials, XEOMIN® received FDA approval for aesthetic use in 2011.

HOW DO I KNOW IF XEOMIN® IS RIGHT FOR ME?
If you are an adult with moderate to severe glabellar lines (frown lines between the eyes), XEOMIN® may be right for you. Talk to your doctor to discuss the benefits and risks of treatment. Do not take XEOMIN® if you are allergic to botulinum toxin or any of the other ingredients in XEOMIN®. You should also not take XEOMIN® if you have had an allergic reaction to any other botulinum toxin product or have a skin infection at the planned injection site.

WHAT CAN I EXPECT DURING TREATMENT?
During treatment, which usually takes about 10-20 minutes, your doctor will inject XEOMIN® (incobotulinumtoxinA) for injection, for intramuscular use, into the muscles in your forehead that cause frown lines between your brows. No anesthesia is required; however, your physician may use a topical anesthetic or cold pack to reduce any discomfort.

WHEN CAN I EXPECT TO SEE RESULTS?
In clinical trials, some patients observed visible smoothing as early as 3-4 days after injection. The median first onset of effect was less than a week. The maximum effect occurred at 30 days. The typical duration of effect was up to 3 months in clinical trials but may last significantly longer or shorter in individual patients.

PLEASE SEE THE XEOMIN® MEDICATION GUIDE AND FULL PRESCRIBING INFORMATION FOR A COMPLETE DISCUSSION OF THE RISKS AND BENEFITS OF TREATMENT.

Questions about BOTOX® Cosmetic

Will I see results quickly?

For moderate to severe forehead lines, frown lines, and crow's feet lines you may begin to see results 1-2 days, with full results in 30 days. For moderate to severe vertical bands connecting the neck and jaw you should see results in 1-2 days with full results in 14 days.

How much does it cost?

Although the cost of BOTOX Cosmetic is based on many factors such as geographical location, provider cost and areas treated the average cost of treatment for moderate to severe forehead line, frown line, and crow's feet is $400-600.

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How long is the recovery time after treatment?

Treatment requires minimal downtime. So you can return to your daily routine immediately after you leave your specialist’s office.

How long does BOTOX Cosmetic last?

Results for moderate to severe forehead lines, frown lines, and crow's feet lines can last up to four months. BOTOX Cosmetic is a temporary treatment, so it’s important to stay on top of appointments. Treatments should be spaced at least 90 days apart. So whenever you get treated with BOTOX Cosmetic be sure to book your next appointment on the way out.

How many units do you need?

For forehead lines, frown lines, and crow's feet lines the FDA-approved amount of BOTOX Cosmetic that can be injected are 20 units for moderate to severe frown lines, 20 units for moderate to severe forehead lines and 24 units for moderate to severe crow’s feet (12 on each side).

How much research has gone into BOTOX Cosmetic?

BOTOX Cosmetic has over 20 years of research and innovation, approved in 100 countries, and is the most studied treatment of its kind. Its safety and efficacy are documented in 574 peer-reviewed scientific articles.

How are lines formed?

A combination of factors, such as reduction of collagen or sun exposure, can cause facial lines. Repeated muscle contractions cause skin to furrow and fold, resulting in facial lines. BOTOX Cosmetic works beneath the surface and temporarily reduces the underlying muscle activity that causes moderate to severe frown lines, crow’s feet, forehead lines in adults — to help them look better.

What is it?

BOTOX Cosmetic is a prescription injectable medical aesthetic treatment that temporarily improves the appearance of moderate to severe forehead lines, crow's feet, frown lines, and vertical neck bands connecting the neck and jaw in adults.

How is it made?

BOTOX Cosmetic is made in a room where the air is circulated 200x an hour. At every step of packaging, shipping, and delivery the maker of BOTOX Cosmetic keeps tabs on every vial’s temperature to ensure consistent quality. Each and every vial is monitored for potential contamination 24 hours of every day to ensure BOTOX Cosmetic meets the highest quality and safety standards.

BOTOX® Cosmetic

The first and only BOTOX® Cosmetic is FDA approved to temporarily improve the look of moderate to severe frown lines, crow's feet, forehead lines, and vertical bands connecting the neck and jaw (platysma bands) in adults.

Tried, Trusted, Proven…

With over 20 years of research and innovation, BOTOX® Cosmetic is the most studied product of its kind with more than 574 peer-reviewed articles in scientific and medical journals.

The Science Behind BOTOX Cosmetic

BOTOX Cosmetic works beneath the surface and temporarily reduces the underlying muscle activity that causes moderate to severe frown lines, crow’s feet, forehead lines and vertical bands connecting the neck and jaw.Questions about BOTOX® Cosmetic.

RHA REDENSITY™ INJECTION

The first and only FDA-approved filler for injection into both the superficial dermis and dermis to treat dynamic perioral rhytids.

MAY BE APPROPRIATE FOR PATIENTS WHO:

Need correction with a superficially placed filler in the dermis
Desire a natural look and feel without unwanted heaviness Radiesse® Dermal Filler is made of calcium-based microspheres suspended in a water-based gel, and is injected into the skin through a simple and minimally invasive procedure. RADIESSE dermal filler is the ideal choice for total facial contouring. It can restore a healthy, youthful appearance, enhance your existing features, help you defy age and gravity, and increase your confidence – all without invasive surgery or scarring.

Results that last up to 12 months*

Patient’s lipstick lines were improved with 0.7 mL of RHA Redensity®, and her dynamic wrinkles and folds in her lower face were improved with 1.5 mL of RHA® 2 and 1.0 mL of RHA® 3. Images captured before and two weeks after treatment. Results may vary.

RHA® 2 INJECTION

Elegant softening for moderate to severe dynamic wrinkles and folds.

MAY BE APPROPRIATE FOR PATIENTS WHO:

Need correction for areas such as radial cheek lines
Desire a natural, soft-focus look

Results that last up to 12 months*

Patient’s dynamic wrinkles and folds in her lower face were improved with 3.2 mL of RHA® 2. Images captured before and two weeks after treatment. Results may vary.

RHA® 3 INJECTION

Dynamic volume for the lips and the dynamic wrinkles and folds around them

MAY BE APPROPRIATE FOR PATIENTS WHO:

Want to enhance the fullness and contour of their lips
Need correction for areas such as marionette lines and oral commissures
Desire a natural look with a moderately robust filler

Results that last:

Up to 15 months in wrinkles and folds

Patient’s lipstick lines were improved with 0.65 mL of RHA Redensity®, and her dynamic wrinkles and folds in her lower face were improved with 2.0 mL of RHA® 2 and 1.8 mL of RHA® 4. Images captured before and two weeks after treatment. Results may vary.

RHA® 4 INJECTION

Natural volume for moderate to severe dynamic folds and deeper deficits

MAY BE APPROPRIATE FOR PATIENTS WHO:

Need correction with a deeper-placed filler
Desire a natural look and enhanced volume without obvious ridges

Results that last up to
15 months*

Patient's dynamic wrinkles and folds in her lower face were improved with 3.6 mL of RHA® 4. Images captured before and two weeks after treatment. Results may vary.dynamic wrinkles and folds in her lower face were improved with 3.6 mL of RHA® 4. Images captured before and two weeks after treatment. Results may vary.

Radiesse® Dermal Filler

Radiuses Dermal Filler is made of calcium-based microspheres suspended in a water-based gel, and is injected into the skin through a simple and minimally invasive procedure. RADIESSE dermal filler is the ideal choice for total facial contouring. It can restore a healthy, youthful appearance, enhance your existing features, help you defy age and gravity, and increase your confidence – all without invasive surgery or scarring.

BUILD COLLAGEN AND ELASTIN WITH RADIESSE

Radiesse builds your unique structural contours by stimulating collagen and elastin production. Results are immediate, natural, and subtle, for a look that perfectly complements your unique beauty.

Questions about Radiesse® Dermal Filler

What is Radiuses?

Radiesse is a dermal filler that is FDA-approved to smooth moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases that extend from the corner of your nose to the corner of your mouth). Radiesse is also used for correcting volume loss in the back of the hands.

How is treatment with Radiesse performed?

Radiesse is injected under the skin in a quick procedure that can be done over the lunch hour.

How soon will I see results with Radiuses, and how long will they last?

Immediately upon injection, Radiesse helps smooth out lines and wrinkles. The natural-looking results last a year or more in many patients.

What are the side effects of treatment with Radiesse?

Common side effects of Radiesse include bruising, redness, swelling, pain, and itching at the site of injection. For a more comprehensive list of side effects for Radiesse, refer to the patient information guides found here.

Where can I find out more about Radiesse?

To get more personalized information, the best thing to do is to schedule a consultation with Laser Medical Center.

KYBELLA®

The active ingredient in KYBELLA® is synthetic deoxycholic acid. Deoxycholic acid is a naturally occurring molecule in the body that aids in the breakdown and absorption of dietary fat. When injected into the fat beneath the chin, KYBELLA® destroys fat cells, and once destroyed, these cells can no longer store or accumulate fat. This results in a noticeable reduction in fullness under the chin, revealing an improved chin profile.

HOW MANY TREATMENTS WILL I NEED

Your specialist will create a tailored treatment plan based on your chin profile. At each treatment, you will be given multiple small injections under your chin. You may receive up to 6 treatment sessions, spaced at least 1 month apart. Many patients experience visible results in 2 to 4 KYBELLA® treatments. 59% of patients received 6 treatments in clinical studies.

In clinical studies, results for KYBELLA®-treated patients who had

A ≥1-grade composite combined physician- and patient-rated improvement were 8% (1 treatment), 28% (2 treatments), 43% (3 treatments), 55% (4 treatments), 66% (5 treatments) and 72% (6 treatments), compared with 2% (1 treatment), 7% (2 treatments), 12% (3 treatments), 14% (4 treatments), 15% (5 treatments), and 22% (6 treatments) of patients treated with placebo
≥2-grade composite combined physician- and patient-rated improvement were 0% (1 treatment), 0.2% (2 treatments), 0.8% (3 treatments), 3.5% (4 treatments), 3.9% (5 treatments) and 15% (6 treatments) compared with 0% (1 treatment), 0.2% (2 treatments), 0.2% (3 treatments), 0.5% (4 treatments), 0.2% (5 treatments), and 1.5% (6 treatments) of patients treated with placebo

WHAT ARE THE POSSIBLE SIDE EFFECTS?

KYBELLA® can cause serious side effects, including injection site problems such as bruising, hair loss, open sores (ulcers), and damage and tissue cell-death (necrosis) around the injection site or trouble swallowing and nerve injury in the jaw that can temporarily cause an uneven smile or facial muscle weakness. In clinical studies, nerve injury in the jaw resolved on its own in a median of 44 days (range of 1 to 298 days), and trouble swallowing resolved on its own in a median of 3 days (range of 1 to 81 days).

The most common side effects are swelling, bruising, pain, numbness, redness and areas of hardness around the treatment area. These are not all of the possible side effects of KYBELLA®. Call your healthcare provider if you develop open sores or drainage from the treatment area or for medical advice about side effects.Will I see results quickly?

For moderate to severe forehead lines, frown lines, and crow's feet lines you may begin to see results 1-2 days, with full results in 30 days. For moderate to severe vertical bands connecting the neck and jaw you should see results in 1-2 days with full results in 14 days.

HOW LONG WILL RESULTS LAST?

When injected into fat under the chin, KYBELLA® causes the destruction of fat cells. Once destroyed, those cells cannot store or accumulate fat. After reaching your desired aesthetic, further treatment is not expected.

WHAT IS THE AVERAGE TREATMENT COST?

Your cost not only includes the price of the product, but more importantly, the skill and expertise of the healthcare professional who is administering your treatment. Look for someone who is licensed and trained and has experience treating patients with KYBELLA®. It is important to find an experienced specialist who will take the time to understand your treatment goals and develop a treatment plan that is right for you.

HOW MANY PEOPLE HAVE BEEN TREATED WITH KYBELLA®?

KYBELLA® has been the focus of a global clinical development program involving over 20 clinical studies. More than 1600 people were treated with KYBELLA® in these studies.

IS KYBELLA® RIGHT FOR ME?

Only you and your doctor can decide if KYBELLA® is right for you. If you’re bothered by fullness under your chin and wish to avoid surgery, ask your doctor about KYBELLA®.

It is not known if KYBELLA® is safe and effective for the treatment of fat outside of the submental area or in children under 18 years of age.

Injectables and Fillers